If a mum or dad of your proband is known to hold the pathogenic variant discovered within the proband, the risk towards the sibs of inheriting the pathogenic variant is fifty%. As a result of lessened penetrance, sibs who inherit the pathogenic variant may or may not build aHUS (see https://industrial-boiler-rental09876.blogscribble.com/32535604/examine-this-report-on-air-handling-units-ahus