Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals within the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have determined recurrent mutations in genes regulating tumor cell-microenvironment inte... https://orlandog802kmq8.creacionblog.com/profile