Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators from the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, wh... https://barbarai555gas8.wikipublicist.com/user