Chemotherapy was potentiated by E7449 and solitary agent had considerable antitumor action in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, probably by way of TNKS inhibition. Per this chance, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and considerably altered expression of Wnt https://jeffreyrydim.full-design.com/5-essential-elements-for-apigenin-72307228